DSIP + Ipamorelin · sleep + GH-pulse stack
Nighttime peptide stack. DSIP for slow-wave sleep enhancement; ipamorelin for the GH pulse coupled to slow-wave sleep. Community-validated for sleep architecture, not formally trialled.
Mechanism rationale
GH pulses are coupled to slow-wave (deep) sleep in normal physiology. DSIP (delta sleep-inducing peptide) was isolated in 1977 from rabbit cerebral venous blood during electrically-induced sleep and is hypothesised to enhance slow-wave architecture, though the mechanism remains incompletely characterised. Ipamorelin triggers a GH pulse via the ghrelin receptor. The community rationale: take both before bed so the deeper sleep DSIP enables coincides with the GH pulse ipamorelin triggers, producing better sleep + amplified anabolic effect than either alone. The pairing is common in nighttime peptide protocols among the recovery-focused community.
Standard dose schedule
DSIP 100 to 200 mcg sub-q + ipamorelin 100 to 300 mcg sub-q, both 30 to 60 minutes before bed. Cycles 4 to 8 weeks. Reconstitution: 5 mg vials in 5 mL bacteriostatic water (1 mg/mL each). Some users add 100 mcg CJC-1295 no-DAC for the GHRH-axis prime.
Not medical advice. Reconstitution math at /tools/reconstitution-calculator.
The honest read
DSIP is one of the weakest evidence bases in the peptide catalog. Mostly Eastern European and Russian research from the 1980s-1990s; modern peer-reviewed trials are sparse. Subjective sleep-improvement reports are common but uncontrolled. Ipamorelin's GH-pulse data is real but the slow-wave-sleep coupling claim is mechanism-plausible, not directly trialled in this combo. The honest read: this stack is community practice with thin underlying evidence.
What both compounds share
DSIP may interact with sedative medications (benzodiazepines, Z-drugs, alcohol); additive GABAergic effect is plausible. Ipamorelin's GH-axis effects share the cancer-promotion theoretical concern as the broader GH-secretagogue category. Anyone with serious sleep pathology (obstructive sleep apnea, narcolepsy) should be evaluated by a sleep medicine specialist before assuming peptide stacks address the diagnosis. Pregnancy + breastfeeding off-limits.
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Last reviewed 2026-04-29. Stack pages refresh when literature, supply, or community practice shifts materially. Email partner@panya.health if you spot something we have wrong.