17 posts on this topic, sorted most recent first.
Rapid weight loss is associated with bone density changes. The GLP-1 trial data on bone is more nuanced than the headlines suggest. Here's what's known, what's contested, and what to do about it.
Rapid weight loss can shift kidney function metrics in ways that look concerning but usually aren't. Here's what to track, what's normal, and when the labs mean something.
The mental health conversation around GLP-1s has gotten louder in the last year. Some of the signal is real and worth taking seriously. Some is noise. Here's the honest separation.
GLP-1s slow gastric emptying, which slows gallbladder contraction, which can produce stasis and stones. The counterintuitive prevention involves more fat, not less.
Rapid weight loss can trigger gout flares in patients prone to them. The mechanism is well-understood, the pattern is predictable, and the prevention is mostly straightforward.
Anesthesiologists are now routinely asking about GLP-1 use before procedures. The reason is real, the timing matters, and the conversation often happens too late if you don't bring it up first.
Tirzepatide is contraindicated in pregnancy, but the timing question is more nuanced than 'stop when you decide to try.' Here's the protocol most prescribers use, and why it usually doesn't get explained at the appointment.
The pancreatitis warning on GLP-1s has been around since the early days of the class. The accumulated evidence after 8 years of widespread use is more reassuring than the warning suggests, but the patient-level decision still has nuance.
Every tirzepatide prescription carries an FDA boxed warning about thyroid C-cell tumors. The data behind the warning is more specific than the warning itself, and it matters for who actually shouldn't take the drug.
Lilly has redesigned the Mounjaro pen multiple times since 2023 and ships region-specific variants. Most pen-appearance changes are legitimate. The few that aren't matter.
The Australian regulator added a contraception note to the tirzepatide label in late 2025. The effect they're flagging is real but narrower than the headlines suggested. If you're on combined oral contraceptives, here's what to actually do.
Rapid weight loss is a known risk factor for gallstone formation. Tirzepatide produces rapid weight loss. The math is straightforward. The clinical signals you need to know about and the things that meaningfully reduce risk are less straightforward.
Tirzepatide isn't recommended in pregnancy. The reasons matter. The pause-before-trying timeline matters more. The conversations about this are usually rushed, often during a brief appointment, and they leave women holding the harder questions alone.
A friend got scheduled for elective surgery and her surgeon told her to pause tirzepatide for a week before. Her telehealth provider had no idea this was a thing. The list of reasons to pause is longer than most providers acknowledge, and pausing is mostly fine.
The semaglutide and tirzepatide effect on alcohol intake is real and well-documented. The mechanism is partly understood, the long-term safety data is thin, and the practical advice for users on the drug is more nuanced than 'one drink is fine.' What the 2026 SURMOUNT-OASIS and downstream trials add.
Eight physical tells on a real Eli Lilly Mounjaro pen, what counterfeiters get wrong, and how to sanity-check a vial or pen from any source before you inject. Updated April 2026.
What actually happens when you start tirzepatide. What is common, what is rare, what is serious, what to do about each.